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Abstract Biocatalytic processes are highly selective and specific. However, their utility is limited by the comparatively narrow scope of enzyme‐catalysed transformations. To expand product scope, we are developing biocompatible processes that combine biocatalytic reactions with chemo‐catalysis in single‐flask processes. Here, we show that a chemocatalysed Pictet‐Spengler annulation can be interfaced with biocatalysed alcohol oxidation. This two‐step, one‐pot cascade reaction converts tyramine and aliphatic alcohols to tetrahydroisoquinoline alkaloids in aqueous buffer at mild pH. Tryptamine derivatives are also efficiently converted to tryptolines. Optimization of stoichiometry, pH, reaction time, and whole‐cell catalyst deliver the tetrahydroisouinolines and tryptolines in >90 % and >40 % isolated yield, respectively, with excellent regioselectivity. 

Dinitroalkanes are powerful synthetic building blocks because of the versatility of the 1,3-dinitro motif. Here, we show that dinitroalkanes can be synthesized from aliphatic aldehydes in a three-step cascade reaction catalysed by phosphate buffer and the amino acid lysine. We further show that this methodology can be expanded to limited alcohol substrates (1-butanol and 1-pentanol) with the inclusion of a biocatalysed alcohol oxidation. Simultaneous addition of all reagents gives a maximal yield of 52% of 3-(nitromethyl)hexane, derived from 1-butanol and nitromethane, whereas staggering the introduction of the amino acid catalyst and nitromethane substrate boosts the yield to 71% of 3-(nitromethyl)hexane with near-quantitative consumption of the n-butyraldehyde intermediate. Taken together, this work presents a mild synthetic method that couples multi-step catalytic cascades generate 1,3-dinitroalkanes. 

This search for magnetic monopoles (MMs) and high electric charge objects (HECOs) with spins 0, $1/2$, and 1, uses for the first time the full MoEDAL detector, exposed to $6.46{\mathrm{fb}}^{-1}$proton-proton collisions at 13 TeV. The results are interpreted in terms of Drell-Yan and photon-fusion pair production. Mass limits on direct production of MMs of up to 10 Dirac magnetic charges and HECOs with electric charge in the range $10e$to $400e$, were achieved. The charge limits placed on MM and HECO production are currently the strongest in the world. MoEDAL is the only LHC experiment capable of being directly calibrated for highly ionizing particles using heavy ions and with a detector system dedicated to definitively measuring magnetic charge. Published by the American Physical Society2025 

The geographical ranges of many mammals and their associated parasites are dynamic. Comprehensive documentation of these communities over time provides a foundation for interpreting how changing environmental conditions, driven by accelerating climate change, other anthropogenic disturbances, and natural events, may influence host-parasite interactions. Fleas (Order Siphonaptera) are obligate, hematophagous parasites of birds and mammals with medical interest because of their role in transmitting pathogens. From 2016 to 2019, we sampled the small mammal and associated flea communities in El Malpais National Conservation Area (El Malpais) in Cibola County, New Mexico. Among 898 mammalian specimens, 925 fleas representing 29 species were collected from 18 host species. Pleochaetis exilis was the most abundant flea species, composing 27% of the total fleas collected, whereas Aetheca wagneri was the most prevalent flea species, parasitizing 8% of the community sampled. Across a total of 284 hosts recorded with fleas, A. wagneri, Malaraeus eremicus, and Peromyscopsylla hesperomys adelpha parasitized the most host species (n = 6 each). Onychomys leucogaster (Wied-Neuwied, 1841), the northern grasshopper mouse, a rodent highly implicated in plague dynamics, was host for the highest number of flea species (n = 15), followed by Peromyscus truei (Shufeldt, 1885) (n = 10). Our aims are to (a) describe the flea-mammal assemblage of a central New Mexico site, creating a baseline for diversity against which changing patterns of association can be assessed over time; (b) identify previously unrecognized host associations; and (c) examine infestation parameters, including the relationships of flea prevalence and mean abundance to host sex, host abundance, and seasonality. As such, our study exemplifies the Documentation and Assessment phases of the DAMA protocol (Document, Assess, Monitor, Act), a central component of exploring distribution and diversity of complex pathogen-host communities across space and time that are essential to a proactive understanding of emerging disease. 

The Breakthrough Starshot Initiative aims to send a gram-scale probe to our nearest extrasolar neighbors using a laser-accelerated lightsail traveling at relativistic speeds. Thermal management is a key lightsail design objective because of the intense laser powers required but has generally been considered secondary to accelerative performance. Here, we demonstrate nanophotonic photonic crystal slab reflectors composed of 2H-phase molybdenum disulfide and crystalline silicon nitride, highlight the inverse relationship between the thermal band extinction coefficient and the lightsail’s maximum temperature, and examine the trade-off between minimizing acceleration distance and setting realistic sail thermal limits, ultimately realizing a thermally endurable acceleration minimum distance of 23.3 Gm. We additionally demonstrate multiscale photonic structures featuring thermal-wavelength-scale Mie resonant geometries and characterize their broadband Mie resonance-driven emissivity enhancement and acceleration distance reduction. More broadly, our results highlight new possibilities for simultaneously controlling optical and thermal response over broad wavelength ranges in ultralight nanophotonic structures. 

We report on a search for magnetic monopoles (MMs) produced in ultraperipheral Pb-Pb collisions during Run 1 of the LHC. The beam pipe surrounding the interaction region of the CMS experiment was exposed to $184.07\mathrm{\mu }{\mathrm{b}}^{-1}$of Pb-Pb collisions at 2.76 TeV center-of-mass energy per collision in December 2011, before being removed in 2013. It was scanned by the MoEDAL experiment using a SQUID magnetometer to search for trapped MMs. No MM signal was observed. The two distinctive features of this search are the use of a trapping volume very close to the collision point and ultrahigh magnetic fields generated during the heavy-ion run that could produce MMs via the Schwinger effect. These two advantages allowed setting the first reliable, world-leading mass limits on MMs with high magnetic charge. In particular, the established limits are the strongest available in the range between 2 and 45 Dirac units, excluding MMs with masses of up to 80 GeV at a 95% confidence level. Published by the American Physical Society2024